Human Growth Hormone

The Most Complete and Accurate Human Growth Hormone Guide in the World


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HGH or the Human Growth Hormone is an anabolic, proteinaceous hormone, which is secreted by the Pituitary gland of the endocrinal system. Recent clinical studies have substantiated the crucial and pivotal role that HGH plays, in reversing the effects of ageing, boosting physical and mental health and giving an overall youthful and energetic life.

HGH.org promises comprehensive, wide-spread, and consistent data about the Human Growth Hormone. This website brings to you all that you need to know about the Human Growth Hormone (HGH), its far-reaching benefits , clinical trials and research studies conducted on HGH, precautionary measures that you need to follow, HGH supplementation, and complete information about the various HGH products that are available. HGH.org is your guide to all the information you ever needed on the Human Growth Hormone.



Understanding the Human Growth Hormone

The Human Growth Hormone is a protein based hormone, manufactured and released by the Adenohypophysis or the anterior part of the Pituitary gland. The hormone comprises of 191 amino acids, and is naturally synthesized, stored, and released by the Somatotrophs (cells located in the anterior lobe of the Pituitary). It plays a pivotal role in the management of the body�s growth and development, metabolism, cell replication and regeneration, and repair of wear and tear.

The Human Growth Hormone (also termed as Somatotropin), helps tissue repair, directs the replacement of cells, controls brain functions, maintains good bone density, helps sustain an ideal body weight, induces good deep sleep and also stabilizes the mood.

Factors that Control the Natural Secretion of the Human Growth Hormone

The production and release of HGH is governed by several factors:


Growth Hormone Releasing Hormone (GHRH): secreted by the Hypothalamus, this hormone acts as the principal controller of the Growth Hormone, and regulates, both, the synthesis and the release of the Growth Hormone from the Pituitary.
Somatostatin (SS): is a peptide-hormone synthesized by the Hypothalamus and various other tissues in the body. Somatostatin slows down the Growth Hormone release from the Pituitary.
Ghrelin: this hormone is secreted by the stomach, and its function is to augment the release of HGH from the Pituitary.
Sex hormones - Androgen and Estrogen also influence the secretion of HGH
Insulin-like Growth Factor (IGF-1): High blood levels of IGF-I (secreted by the liver in response to HGH stimulation) leads to reduced secretion of the Growth Hormone as a part of negative feedback. It suppresses the Somatotrophs (cells of the anterior Pituitary) and stimulates the release of Somatostatin from the Hypothalamus, thus diminishing HGH release.
• High levels of Growth Hormone (in the blood) also gives a feed back, to stall GHRH secretion, and has an inhibitory effect on the secretion of any further HGH.
Deep sleep plays a significant role in the release of the Growth Hormone
Exercise and physical activity
Nutrition, hypoglycemia, and fasting are other important influencing factors


In consequence to these factors, the Pituitary secretes the HGH in spurts and surges, throughout the day, with secretions reaching a peak at regular time periods of three to five hours.

Functions / Effects of the Human Growth Hormone in the body

The Human Growth Hormone serves innumerable vital functions in the body:


Growth: the Growth Hormone signals the liver and other tissues in the body, to secrete IGF-I. IGF-I encourages the production of Chondrocytes (cartilage cells), resulting in bone growth. IGF-I is also an important component responsible for muscle growth. It causes differentiation and proliferation of Myoblasts (muscle cells). Amino acid uptake and protein synthesis in muscle and other tissues, also takes place under the direction of GH. Thus, HGH plays a crucial role in increasing the height in children and adolescents.
Metabolism: the Growth hormone exerts important effects on protein, lipid and carbohydrate metabolism. In certain cases, the Growth Hormone exerts a direct effect on the metabolism. While, in others, IGF-I is thought to be the fundamental intermediary component, while in still others, both, direct and indirect effects come in to play.
Protein metabolism: Growth Hormone encourages and triggers protein anabolism (building) in many tissues. There occurs an increased amino acid uptake, enhanced protein synthesis and reduced oxidation of proteins.
Fat metabolism: the Human Growth Hormone augments the utilization of fat by triggering triglyceride break-down (lipolysis) and oxidation in the Adiposites (fat cells).
Carbohydrate metabolism: HGH maintains normal blood glucose levels. It has an anti-Insulin activity, by curbing the Insulin�s ability to stimulate the uptake of glucose by the peripheral tissues.
� HGH enhances calcium preservation, and augments bone mineralization.
� It enhances lean muscle mass formation.
� Reduces the absorption of glucose by the liver
� Stimulates protein synthesis
� It plays a critical role in cell duplication, and thereby, stimulates the growth of various body tissues.
� It perks up and sustains a good defense and immune mechanism in the body, thus, reducing the body�s vulnerability to infections.
� Helps stave off premature aging, and preserves youthfulness and vigor


Growth Hormone Imbalances

HGH deficiency as well as HGH excess results in disorders.


Human Growth Hormone Deficiency:
A deficiency state can result from an insufficiency in the synthesis of the Growth Hormone and/or a failed target cell's response to the hormone.
Clinically, a shortage of the Growth Hormone or a flaw in its binding to the receptor cell, is manifested as Growth Retardation and Dwarfism.
Human Growth Hormone Excess:
This disorder occurs when there is too much secretion of the hormone, usually, due to tumors of the Pituitary. Clinical manifestations are Gigantism (in children) and Acromegaly (in adults). Clinical signs of Acromegaly include, overgrowth of the extremities, soft-tissue swelling, abnormalities in the jaw bone and cardiac disorders.


Need for Synthetic Human Growth Hormone

Optimum levels of the Growth Hormone are found in the age group of 15 to 30 years. With progressing age, the normal levels of HGH start falling. Research substantiates the fact that, the GH level drops by about 14 %, every 10 years, in both sexes, consequently leading to exhaustion and weariness, weight gain, fragile and weak bones, poor calcium retention, cardio-vascular diseases (high cholesterol levels, atherosclerosis, and heart attacks), memory related disorders, and changed sleep patterns. Thus, maintaining sufficient levels of HGH in the body is vital for normal growth, and to maintain good health.

In the recent years, HGH replacement therapies have become extremely popular, especially, to combat the signs of aging and to attain an ideal body weight.

Bio-synthetic Human Growth hormone is also referred to as Somatropin and Recombinant Growth Hormone (rhGH). Artificial HGH is manufactured through Recombinant DNA technology. The Recombinant growth method is very safe, and is used to synthesize other therapeutic proteins like - Insulin. HGH is no longer taken out from animal or human sources, like it used to be done formerly. The most frequently used technique for the manufacture of HGH, is the Protein Secretion technique or the Mouse-Cell technique. Both these methods, produce bio-synthetic HGH that is identical to the GH synthesized naturally by the Pituitary gland in our body.

HGH supplementation therapy offers a host of important health benefits. The constructive health benefits of the hormone have been supported by copious amount of research and scientific studies.

Benefits of Synthetic HGH Replacement Therapy

Therapeutically, artificial HGH supplements offer several noteworthy benefits. These include:


• Synthetically produced Growth Hormone has been used clinically to manage children's growth disorders (Dwarfism) and adult Growth Hormone Deficiencies and imbalances, which become clinically apparent in the form of truncal obesity (excessive fat deposition around the abdomen), short stature, growth failure, muscle weakness, fatigue, etc. In adults, the therapy is recommended for use, when the Pituitary gland is not producing sufficient quantities of the natural Human Growth Hormone. If one shows symptoms of AGHD or Adult Growth Hormone Deficiency, such as lassitude, tiredness, and low energy levels, slow healing of injuries, and slow muscle mending, he would be a possible candidate for the Growth Hormone replacement therapy. Physician guided Human Growth Hormone therapy is endorsed for use by adults, over age of 35 years, in the United States. Even though, the Human Growth Hormone replacement therapy, when suitably prescribed, is safe, non toxic, and non detrimental, and has no major side effects, one should be prudent, and always consult a physician or an endocrinologist, to ensure appropriate dosage, frequency, and suitability with respect to oneself.
• Fat reduction: HGH therapy helps get rid of unwanted fat (through lipolysis), and helps diminish the body weight, while, at the same time, it helps maintain good muscle strength and enhances the lean muscle mass.
• Helps impede the onslaught of aging: Medical journals have demonstrated an exceptional ability of the hormone to successfully turn around the process of aging.
• There occurs improved cardiac output, lowered blood pressure, and improved cholesterol levels after embarking up on HGH therapy.
• HGH replacement enhances immune mechanism, defense functions and peps up the resistance of the body.
• Enhances libido and sexual performance
• Encourages hair re-growth
• Promises a younger, tauter, firmer and wrinkle-free skin
• Enhances energy levels:
• HGH replacement increases the density of bones, making bones stronger, and significantly reducing the incidences of bone fractures
• HGH boosts mental abilities and efficiently checks sleep disorders and insomnia.


Justifiably, the Human Growth Hormone has several vital and key functions in our body, and is considered the master hormone. Maintaining acceptable levels of HGH is fundamental to good health, optimal growth and the general well being of the individual.