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Brief and Straightforward Guide on: Creatine

What is Creatine?

Creatine is a nitrogenous organic compound occurring naturally in the body. It plays the important role of supplying energy to the muscles. Creatine is synthesized in the human body (naturally) from amino acids (L-arginine L-methionine, and glycine), chiefly, in the liver and kidney. It is conveyed through the blood, for use by the muscles. Nearly 95 % of the body's total Creatine is present in skeletal muscles. The remaining 5 % is located in the heart or the brain.

In human beings, approximately, half of the stored Creatine is generated from food (mainly meat and fish). Vegetables do not contain Creatine, thus, vegetarians demonstrate lower levels of muscle Creatine.

Primary Function of Creatine

Creatine participates in the complex muscle contraction process, to boost muscle energy. Adenosine Triphosphate, (ATP), is the fundamental component for muscle contraction. The more ATP you make accessible to the muscles, the more energy is generated. This energy powers body-building and enhances performance. Normal levels of ATP in the body allow one, only a few seconds of high - intensity energy. Creatine fuels ATP development, which promises:

• Sustained great-intensity and power-workouts
• Enormous amounts of energy for muscle contraction
• Immensely improved power and muscle size

Creatine supplements

Creatine is one of the most extensively used sports supplements in the market today. Its principal use is in strength-providing, and bulk-building exercises, and enhancing performance for high - intensity sports, it maximizes workouts, and gives one an edge in anaerobic athletic competitions.

Extensive research over the last decade has shown that oral Creatine supplementation of 5 to 20 grams per day, seems to be very safe and bereft of any adverse side-effects, while, at the same time, it effectively improves the physiological response to resistance exercise.

There are various forms in which Creatine supplements are dispensed, but the most frequently used are - Creatine monohydrate, Creatine citrate, and Creatine ethyl ester. Creatine is administered as a powder mixed into a drink, or as a capsule or a caplet. Once consumed, Creatine is extremely bio-available.

Creatine supplements for body builders and sports persons

Creatine supplements aid athletes, helping him or her increase high-intensity athletic performance. Though, researchers have known of the use of Creatine as an energy source by skeletal muscles, since, the beginning of the 20th century, they were well-liked as a performance-enhancing supplement in 1992.

Creatine has become increasingly popular with the body builders to improve their ability to build lean muscle tissue. These supplements stimulate protein synthesis, provide additional energy and help you do more work. Also, when there is an abundance of Creatine phosphate in the muscle, the muscle holds more water, becomes "volumized" or "super-hydrated." The more volumized a muscle is, the more it will encourage protein synthesis, and deter protein breakdown."

Creatine supplements promise that added muscle - building energy that you need to get a more useful and better power work-out. Administering Creatine an hour prior to a high-intensity workout session is beneficial, because, Creatine is rapidly absorbed in to the bloodstream and gets instilled in to the muscle tissue. If you do not use it, you lose it. Anabolic sports persons benefit most from the use of Creatine. It builds ATP, which provides you with a burst of intense energy. Creatine is wonderful for bodybuilders, wrestlers, and people playing hockey, baseball, basket ball, football, and soccer.

Some researcher’s say, in view of the fact that, the body gains about 1 kilogram in one week, the gain is due to more water retention within the muscle cells. Conversely, other studies, say that Creatine enhances the action of Satellite cells, making muscle hypertrophy a possibility. Creatine proliferates the number of Myonuclei that Satellite cells will provide to the injured muscle fibers, which in turn, augments the capability of growth of those fibers. This increase in Myonuclei, occurs due to Creatine's capability to augment levels of the Myogenic transcription - factor MRF4.

Importantly, since Creatine is natural, there are no restrictions on its use among athletes.

What is Creatine cycling?

Creatine cycling, or Creatine loading and maintenance, is a regime that helps administer the appropriate dose of Creatine for the highest benefit. Creatine loading phase lasts for 5 days. During this phase, one ingests multiple doses of Creatine everyday, at different time intervals. During the Creatine maintenance phase, one ingests 1 dose of Creatine a day, typically, within an hour before the workout.

You could carefully develop and test your own personal program of inter-changeable Creatine forms (I.e. liquid, bars, chews, etc) and cycling between loading and maintenance regimens, and understand what works best for you. Each time you include a slightly different Creatine formula or form, you augment the muscle size and boost energy levels.

Treating medical conditions through Creatine therapy

Creatine has been shown to cause a reasonable increase in strength in people with a variety of neuromuscular disorders. Creatine supplements have been, and continue to be, assessed as a potential therapeutic approach for the management of muscular, neuro-muscular, neurological and neuro-degenerative diseases, like congestive cardiac failure, Parkinson’s disease, arthritis, muscular dystrophy, etc. The neuro-protective benefits of Creatine may be due to an increased availability of energy to injured nerve cells or due to a blocking of the chemical pathway that leads to cell death.

Some studies have also indicated that supplementation with Creatine significantly increases intelligence. Another clinical trial found that Creatine supplements greatly enhanced cognitive ability in the elderly


• Prolonged use of huge quantities of Creatine increases the synthesis of formaldehyde in the body, which has the possibility of causing grave unwanted side-effects. However, this risk is mainly theoretical, since, the urinary excretion of formaldehyde, even under heavy Creatine supplementation, does not surpass normal limits.

• Recent research indicates that short - term Creatine supplementation in healthy people is safe, although, those suffering from renal diseases should keep away from it, due to the probable risks of developing renal dysfunction.

• A few long-term studies have demonstrated, that the excessive usage of Creatine causes muscle cramps, on the other hand, other studies show, do not show any reports of muscle cramping in individuals taking Creatine supplements. Dehydration may be the cause for muscle cramping in certain individuals taking Creatine. Thus, drinking additional water is very vital when taking Creatine supplements.

• Short-term or long-term Creatine therapy did not demonstrate any noteworthy effect on the quantitative or qualitative blood and urine markers. No significant changes in the serum metabolic markers, serum electrolytes, red and white whole blood cell hematology, and blood lipid profiles have been demonstrated.

• Creatine, in dosages that are usually used, causes urinary concentration, ninety times higher than normal. The long - term impact of this consequence, has not been assessed thoroughly, but, there is likelihood of developing nephrotoxicity. There is probability for the occurrence of toxicity on the renal tubules and a strong chance of developing kidney stones.

• Creatine has been associated with asthma-like symptoms and experts warn individuals who suffer from any known allergies, from taking the supplementation.

• Some experts warn that the liver function may be altered, and caution is advised to those who have an underlying liver disease, although, studies have shown little or no adverse effect on kidney or liver function from oral Creatine supplements.

• Theoretically, Creatine may alter the action of Insulin. Prudence is advised, in patients suffering from diabetes or hypoglycemia, and in those, taking drugs, herbs, or supplements that affect blood sugar levels. Blood glucose levels need to be observed by a physician and medication adjustments may be needed.

• Creatine is not recommended during pregnancy or breastfeeding.

• If you develop any discomfort or adverse effects, while on Creatine supplements, immediately consult a doctor.

• Taking a physician’s advice and opinion, before consuming any creatine supplements is strongly recommended.