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HGH And Bone Healing
Read the Following article on "HGH And Bone Healing".
There are times when you really cannot avoid an injury. Thus you need to find ways on how to speed up healing and recovery as much as possible so that you can get back to work.
After a fracture, healing is composed of three stages. First there is the early inflammatory phase, which is initiated after hemorrhage caused by vascular injury and the subsequent development of a hematoma. Infiltration of inflammatory cells and of fibroblasts into the area then occurs. These events lead to vascularization of the area and the formation of granulation tissue. The repair phase is characterized by the formation of a callus. It begins with continued vascular ingrowth, secretion of osteoid, and the presence of fibrocollagenous fibers. A temporary callus consisting of cartilage is produced at the site of injury. This initial union develops in the first 4 to 6 weeks and has limited strength; thus, internal/external immobilization of the fracture/fusion site is often appropriate. Osteoblasts continue to be active and replace cartilage with the cancellous bone forming a bridge between the fractured fragments. Cancellous bone may then be converted to compact bone as osteoid deposition continues. In the remodeling phase the process may occur over months to years and consists of restoring the fractured bone to its normal size, shape, and strength. Adequate strength usually develops by 6 months.
Thus we can see here that the main players in these events are osteoblasts.
Osteoblasts increase bone mass all throughout our childhood. This is why when we were children, fractures and injuries heal faster. However, as we grew older, fractures tend to heal slowly. The reason for this is the diminishing levels of human growth hormone in adulthood.
But what is growth hormone? Growth hormone is a protein-based poly-peptide hormone. It stimulates growth and cell reproduction and regeneration in humans and other animals. It is a 191-amino acid, single-chain polypeptide hormone that is synthesized, stored, and secreted by the somatotroph cells within the lateral wings of the anterior pituitary gland. The pituitary stops secreting it at age 30. Now, thanks to modern technology, human growth hormone is now being manufactured artificially to be administered I times when growth factors are clinically needed.
But how exactly does HGH speed up bone healing?
HGH Increases Bone Healing
Because polypeptide hormones are not fat-soluble, they cannot penetrate sarcolemma. Thus, human growth hromone exerts some of its effects by binding to receptors on target cells, where it activates a second messenger. Through this mechanism GH directly stimulates division and multiplication of chondrocytes of cartilage.
HGH also stimulates production of insulin-like growth factor 1 which has growth-stimulating effects on a wide variety of tissues. IGF-1 also has stimulatory effects on osteoblast and chondrocyte activity to promote bone growth.
After a fracture, healing is composed of three stages. First there is the early inflammatory phase, which is initiated after hemorrhage caused by vascular injury and the subsequent development of a hematoma. Infiltration of inflammatory cells and of fibroblasts into the area then occurs. These events lead to vascularization of the area and the formation of granulation tissue. The repair phase is characterized by the formation of a callus. It begins with continued vascular ingrowth, secretion of osteoid, and the presence of fibrocollagenous fibers. A temporary callus consisting of cartilage is produced at the site of injury. This initial union develops in the first 4 to 6 weeks and has limited strength; thus, internal/external immobilization of the fracture/fusion site is often appropriate. Osteoblasts continue to be active and replace cartilage with the cancellous bone forming a bridge between the fractured fragments. Cancellous bone may then be converted to compact bone as osteoid deposition continues. In the remodeling phase the process may occur over months to years and consists of restoring the fractured bone to its normal size, shape, and strength. Adequate strength usually develops by 6 months.
Thus we can see here that the main players in these events are osteoblasts.
Osteoblasts increase bone mass all throughout our childhood. This is why when we were children, fractures and injuries heal faster. However, as we grew older, fractures tend to heal slowly. The reason for this is the diminishing levels of human growth hormone in adulthood.
But what is growth hormone? Growth hormone is a protein-based poly-peptide hormone. It stimulates growth and cell reproduction and regeneration in humans and other animals. It is a 191-amino acid, single-chain polypeptide hormone that is synthesized, stored, and secreted by the somatotroph cells within the lateral wings of the anterior pituitary gland. The pituitary stops secreting it at age 30. Now, thanks to modern technology, human growth hormone is now being manufactured artificially to be administered I times when growth factors are clinically needed.
But how exactly does HGH speed up bone healing?
HGH Increases Bone Healing
Because polypeptide hormones are not fat-soluble, they cannot penetrate sarcolemma. Thus, human growth hromone exerts some of its effects by binding to receptors on target cells, where it activates a second messenger. Through this mechanism GH directly stimulates division and multiplication of chondrocytes of cartilage.
HGH also stimulates production of insulin-like growth factor 1 which has growth-stimulating effects on a wide variety of tissues. IGF-1 also has stimulatory effects on osteoblast and chondrocyte activity to promote bone growth.