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Brief and Straightforward Guide on: Injectable HGHNeed Of Human Growth Hormone
The Human Growth Hormone (HGH) is the master hormone in the human body, and is synthesized and secreted by the endocrinal system. This hormone controls essential functions like: growth and replication of cells in various organs of the body. Some of the essential functions of HGH are - controlling muscle growth, improving bone mineralization and strength, reducing fat deposition, and sustaining good energy levels. The production and secretion of the growth hormone is controlled by Growth Hormone Releasing Hormone (GHRH), which is secreted by the hypothalamus. The GHRH stimulates the pituitary gland to produce Growth Hormone, which is directly released into the blood stream. The Growth Hormone in turn stimulates the liver to produce Insulin like Growth Factor (IGF-1) which stimulates the proliferation of Chondrocytes (cartilaginous cells), promotes differentiation of myoblasts and enhances protein synthesis, which in turn, helps in the growth of other muscles and tissue cells.
HGH also has a significant role to play in controlling the metabolism of proteins, lipids and carbohydrates. Natural GH production is stimulated and controlled by various factors like exercise, nutrition, stress and sleep. In a normal individual, the natural production of the growth hormone peaks in the early 20s and then falls steeply at the rate of 14 % per decade, after the age of 30 years. This in turn, is responsible for various metabolic alterations in the body, namely increased fat deposition and decreased muscle mass. Furthermore, it results in various physical changes including - wrinkles on the skin, reduced levels of energy, etc and psychological changes like increased anxiety, a lack of sense of wellbeing, etc.
Why consider HGH replacement Therapy?
In a the most widely quoted study, published in the New England Journal of Medicine in the early 1990s, administration of bio-synthetic HGH was associated with significant benefits on the participants. These benefits ranged from - enhanced sense of wellbeing, decline in fat deposition in the body, concurrent increase in the lean muscle mass and improved texture and elasticity of the skin reducing wrinkles and deep skin lines. The study also observed other benefits like enhanced immunity, faster recovery after chronic infections or diseases, hastened recovery from injury, etc.
The tremendous benefits of the Growth Hormone has made countless individuals, consider using the wonder hormone. Athletes and sports personalities use the hormone to boost their performance, energy levels and to increase lean muscle mass. Elderly use the hormone to ward off the signs of aging and to get a sense of wellbeing. The hormone is prescribed in children to increase height, especially among children suffering from Growth Hormone deficiency.
FDA regulations related to HGH injections
The use of recombinant HGH in the form of HGH injections is the most effective therapy option, as it shows relatively quicker and lasting results. However, the use of HGH injections is strictly regulated by the US Food and Drug Administration due to several reasons. Firstly, HGH is promoted as a ‘miracle hormone’ and hence, it is looked upon as an all - problem solution, which, technically it is not. Further, though there is some documented evidence about its effectiveness in some clinical studies and research papers, there has been no detailed assessment of the hormone with regards to its safety, effectiveness and ideal dosage. This has resulted in the FDA disapproving the use of HGH injections without the prescription of a qualified and licensed medical professional. FDA approves the use of the drug only for a select set of conditions namely HGH deficiency, Turner’s syndrome, Prader-Willi’s Syndrome, Renal insufficiency, Intra Uterine Growth Retardation and Cachexia. The pharmaceutical companies however, are pushing for the use of the hormone for other conditions like chronic fatigue syndrome, obesity, anti-aging and fibromyalgia.
As per the FDA mandate, a doctor’s prescription is vital for securing the injectable form of HGH from a pharmacy. What‘s more, the hormone needs to be administered under the supervision of the prescribing doctor. Though self administration is simple, regular clinical assessments are mandated to protect the patient against harmful consequences of the therapy.
Limitation of HGH injections
Though it is the most effective, spontaneous and trusted treatment option for the management of Growth Hormone deficiency, it has some limitations:
• Firstly, the cost of the treatment is exorbitant. Depending upon the pharmaceutical company the cost of HGH injections for a month of treatment, would range between $ 800 to $ 3000.
• The complications associated with prolonged use and high dosages are severe and irreversible. These include: the probability of developing diabetes, cardiovascular disorders and colon cancer. Other common side effects include: joint pain, generalized edema, severe headache, hypoglycemia, wrist pain (carpel tunnel syndrome), increased level of LDL in the blood increasing the possibility of developing atherosclerosis, etc.
• HGH injections are not available over the counter, nevertheless, due to rigid FDA norms, black-marketing is rampant. The procurement of the HGH injections without medical prescription is considered illegal and is punishable by law, with imprisonment and fine.
These limitations of HGH injections has resulted in the development of a host of other products like HGH supplements, HGH sprays, Homeopathic HGH, etc. These claim to be safer and equally effective, whilst being available at a fraction of the cost of HGH injections. However, these products have never been clinically tested, and there is no official information about the efficacy and safety of these products. Yet, as per estimates over 100,000 purchase orders are made each year for non HGH injection products.
Ideal HGH injection dosage
HGH injections need to be taken under the guidance of medical professionals. Normally, the first HGH dose is calculated at the rate of 0.01 mg per kg body weight per week. This dosage may be divided into three to five injections over the week and given subcutaneously. This is then closely monitored by the physician to evaluate the ideal dose requirement for the underlying condition. The assessment of the dosage is based on IGF-1 stimulation test and the requirement of the dosage is inversely proportion of the levels of IGF-1 in the blood.