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Brief and Straightforward Guide on: Somatropin

Somatotropin Vs Somatropin

The natural form of the Human Growth Hormone is referred to as Somatotropin, which is a complex protein molecule, comprising of 191 amino acids with a molecular weight of about 22,000 Daltons. Somatotropin is secreted by the pituitary gland which in turn stimulates the liver to produce IGF-1 which is responsible for various metabolic activities. IGF-1 stimulates division and multiplication of chondrocytes of the cartilage, increases calcium retention by the bones, induces protein secretion, promotes lipolysis, and reduces protein degeneration and repairs damaged cells.

On the other hand, Somatropin is a 191 amino acid sequence growth hormone, which is biosynthetically prepared and doesn’t occur naturally. This synthetic hormone is identical to the HGH produced naturally in the body and hence, provides benefits similar to the naturally occurring hormone.

Seatrain (bio-synthetic HGH) is used for the treatment of a host of conditions including short stature and stunted growth in children, Growth Hormone Deficiency in Adults, Cachexia, Chronic Renal Insufficiency and Intra Uterine Growth Retardation (IUGR) in pregnant women. This artificially synthesized hormone is also used in healthy adults for anti aging management, body building and weight loss (fat reduction) purposes. Further, the synthetic hormone is also used for management of weight loss or muscle wasting in HIV patients and intestinal disorders like Short bowel syndrome.

FDA regulations for the use of the Somatropin

FDA strictly regulates the use of the hormone for a few select conditions, due to a lack of adequate critical medical literature and research to prove its efficiency. As per the FDA regulation, Somatropin can't be purchased over the counter and requires a physician's prescription. Also, it is mandated that the therapy (Hormone replacement), has to be supervised by a licensed medical practitioner to avoid any complications or side effects.

Guidelines for the use of Somatropin

• Somatropin medication is given in the form of injections into the muscle (intramuscular) or under the skin (subcutaneous). Since these injections have to be taken several times during the week, it is critical that the location of the injection site be changed on a regular basis to avoid site reaction and localized inflammation

• Somatropin is used for a variety of conditions and the dosage and technique of injection depends upon the condition. It is thus of utmost vitality to consult the physician and follow his/her instructions correctly. Furthermore, overdose is associated with severe complications which are irreversible and irremediable, therefore, a regular evaluation by the medical professional is critical.

• Certain dietary and life style changes are recommended along with the injections to ensure maximum efficacy of the therapy. These have to be followed properly in order to avert any complications or side effects.

• If the medication has to be self administered (as per the physicians directions), it is important to ensure that all instructions are followed regarding mixing of the medication. Avoid shaking the solution vigorously while mixing. Shaking will affect the delicate and complex structure of the somatropin molecule rendering it ineffective.

• Don’t use the medication if you observe any particles or discoloration. Needles and syringes are for one time use only, and should be discarded immediately after the injection.

Precautionary Measures before the use of Somatropin

• Before starting the treatment with somatropin, make sure that the physician is aware about your medical history. All information regarding the past history, medical records, allergies, etc has to be shared with the physician.

• Somatropin may result in complications, especially, if the patient has undergone a major surgery, has a severe respiratory distress or is undergoing therapy for the management of tumors. Further, detailed history regarding diabetes, thyroid or other hormone disorders has to be shared with the physician.

• Special precautions are required when somatropin is used in newborns for management of IUGR or other conditions. It is essential that the injection is mixed with sterile water provided along with the injection, which doesn’t contain benzyl alcohol. Benzyl Alcohol is a preservative which may result in severe complications and sometimes death in new born infants, particularly, during the first month of their life.

• Special precautions are also mandated when somatropin is used in elderly patients and during pregnancy. Consult the physician before starting this treatment in such special situations.

• Somatropin has specific storage requirements, follow the instructions on the product closely. Check for expiry date and discard expired products. Avoid freezing the product. Keep the medicine out of reach of children and pets.

Drug Interactions and Overdose

• Ensure that you have informed your physician about all the over the counter prescriptions that you are using. Use of glucocorticoids has been known to interfere with the action of somatropin. Don’t start or stop any ongoing medications without the doctors approval

• Overdose can present in the form of severe headache, nausea and vomiting, sudden sweating, fatigue, shakiness and confusion. In such situations, contact the emergency room of the nearest hospital. US residents can call US national poison hotline at 1-800-222-1222. Canadian residents are requested to call the local poison control center.

Side Effects of Somatropin

• The side effects include headache, nausea, fatigue, vomiting, muscle pain and generalized weakness. These are an indication of overdose and should be reported immediately.

• Swelling in hands, ankles or legs, joint pain, carpel tunnel syndrome, etc are some of the common side effects. It is essential to inform your doctor about these when they appear.

• Other more serious complications include increased heart beat, breathlessness or difficulty in breathing, increased thirst or urination and dizziness. These are typical symptoms of cardiovascular distress and an indication that the individual may be developing diabetes. Inform the physician immediately.

• Those at high risk include: males, severely obese children, those with severe respiratory or lung problems. These individuals need to be evaluated prior to the initiation of the treatment.

• Overuse of somatropin has also been linked with biochemical changes in the blood composition, with an increase in the levels of LDL and fall in the level of HDL, increasing the possibility of developing atherosclerosis. Inform your doctor immediately if your investigations show any form of deviation from normal.