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Brief and Straightforward Guide on: What Is HGHThe Human Growth Hormone (HGH)
The Human Growth Hormone, a protein formulation, is secreted by the Adenohypophysis or the anterior part of the Pituitary Gland. This single chain, 191 amino acid, poly-peptide hormone, is naturally manufactured, stored, and released by the Somatotrophs (cells located in the anterior lobe of the Pituitary Gland). It encourages growth, and cell production and regeneration in humans by stimulating protein formation.
The Human Growth Hormone (also termed as Somatotrophin), commands the various functions of the body and hence, is the key hormone in the body. It stimulates tissue repair, governs the replacement of the cells, controls brain functions and the functioning of diverse enzymes.
The Anterior Pituitary Gland secretes the HGH in spurts throughout the day, with secretions reaching a peak at regular intervals of three to five hours. The serum concentrations of HGH during the peaks vary from five to forty five ng/mL.
Factors stimulating the natural secretion of Human Growth Hormone
There are several factors that stimulate the secretion of the HGH:
• GHRH or the Growth-Hormone-Releasing-Hormone, released by the Hypothalamus, acts as the primary controller of the amount of HGH secreted by the Pituitary Gland
• Hormone Ghrelin
• Sex hormones, including Androgen and Estrogen also influence the release of HGH
• Deep sleep plays a significant role in the release
• Exercise and physical activity
• Nutrition, hypoglycemia, and fasting are other important influencing factors
Functions performed by the Human Growth Hormone
The Human Growth Hormone serves several vital and essential functions in the body:
• HGH plays a crucial role in increasing the height among children and adolescents.
• HGH increases calcium preservation, and augments bone mineralization.
• It enhances muscle mass.
• Promotes lipolysis (fat break down) and gluconeogenesis (production of glucose from amino acids) in the liver.
• Reduces the absorption of glucose by the liver
• Encourages protein production
• It plays a crucial role in cell reproduction and thereby stimulates the growth of various body tissues.
• Stimulates the defense and immune mechanisms of the body
• Helps prevent premature ageing and preserves youthfulness
Need for Synthetic Human Growth Hormone
Optimum levels of the hormone are found in the age bracket of 21 to 30 years. As one ages, the natural levels of HGH start declining. Research and clinical trials estimate that, every 10 years, the HGH level drops by about 14%, subsequently leading to fatigue and weariness, weight gain, brittle bones, poor calcium retention, cardiovascular diseases (high cholesterol levels, atherosclerosis, and heart attacks), memory related disorders, and altered sleep patterns. Thus, sustaining adequate levels of HGH in the body is vital for normal growth, and to maintain optimum health.
Synthetically manufactured Human Growth Hormone has been used clinically to manage children's growth disorders and adult growth hormone deficiencies which are clinically manifested in the form of truncal obesity, short stature, growth failure, etc. In the recent years, HGH replacement therapies have become exceedingly popular in the fight against ageing and to achieve an ideal body weight.
Synthetic Human Growth hormone (HGH) is also referred to as Somatropin. In mid 1980s, Pituitary derived HGH was substituted by Synthetic Human Growth Hormone for therapeutic purpose. The synthetic Human Growth Hormone is also frequently called Recombinant Growth Hormone (rhGH).
Synthetic HGH is produced through Recombinant DNA technology. The Recombinant growth method is safe, and is used to manufacture other therapeutic proteins like Insulin. HGH is no longer extracted from animal or human sources (like it used to be done previously). The most commonly used method for manufacturing HGH, is the Protein Secretion technique or the Mouse-Cell technique. Both these techniques of manufacturing produce HGH identical to GH naturally produced in the body. HGH supplements offer several significant health benefits. The favorable health benefits of the hormone have been corroborated and backed by numerous researches and scientific studies.
Research reports that the effects on HGH on patients deficient in the hormone comprise of reduction in body fat, increase in muscle mass, enhancement of bone density, augmentation of energy levels, better skin tone, increased sexual functions and enhancement of the overall immunity.
Benefits of synthetic HGH replacement Therapy
Therapeutically, artificial or synthetic HGH supplements grant several benefits. These include:
• Fat reduction: HGH is recommended in certain syndromes, where it helps reduce body weight, whilst maintaining the muscle strength and improving the muscle mass.
• Helps thwart the onslaught of ageing: Medical journals have demonstrated an outstanding ability of the hormone to reverse the process of ageing. HGH supplements promise to take years off you!
• There occurs greater cardiac output, lowered blood pressure, and improved cholesterol levels.
• Enhances immune function and resistance of the body
• Enhances sexual performance
• Promotes hair re-growth
• Promises a younger, tighter, firmer and wrinkle-free skin
• Boosts energy levels: Several recent studies reiterate the role of HGH in improving athletic performance
• Increases bone density, making the bone stronger and reducing the incidences of bone fractures
• HGH enhances mental functioning and effectively checks sleep disorders.
Understandably, the Human Growth Hormone has critical and vital functions, and is considered one of the chief hormones in the body. Maintaining satisfactory levels of HGH in the body is fundamental to good health, optimum growth and general well being of the individual.